CSynth: an interactive modelling and visualization tool for 3D chromatin structure.

ABSTRACT:

Motivation

The 3D structure of chromatin in the nucleus is important for gene expression and regulation. Chromosome conformation capture techniques, such as Hi-C, generate large amounts of data showing interaction points on the genome but these are hard to interpret using standard tools.

Results

We have developed CSynth, an interactive 3D genome browser and real-time chromatin restraint-based modeller to visualize models of any chromosome conformation capture (3C) data. Unlike other modelling systems, CSynth allows dynamic interaction with the modelling parameters to allow experimentation and effects on the model. It also allows comparison of models generated from data in different tissues/cell states and the results of third-party 3D modelling outputs. In addition, we inclu

SUBMITTER: Todd S 

PROVIDER: S-EPMC8128456 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature