Micronized purified flavonoid fraction for the treatment of chronic venous insufficiency, with a focus on postthrombotic syndrome: A narrative review.

ABSTRACT:

Introduction

Postthrombotic syndrome (PTS) is a form of secondary chronic venous insufficiency (CVI) that occurs after deep vein thrombosis (DVT). Effective treatments for PTS are lacking. Micronized purified flavonoid fraction (MPFF) is a venoactive drug used in the treatment of CVI.

Objective

To determine whether MPFF is a good candidate to explore as a therapeutic agent for PTS.

Methods

We performed a narrative review in which we identified 14 systematic reviews, 33 randomized controlled trials, and 19 observational studies that discussed the use of MPFF in CVI, as well as studies that reported on the mechanistic action of MPFF in relation to the pathophysiology of PTS.

Results

MPFF targets a number of pathophysiologic components of PTS. Based on animal mode

SUBMITTER: Li KX 

PROVIDER: S-EPMC8128666 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature