Early detection of radiation-induced lung damage with X-ray dark-field radiography in mice.

ABSTRACT:

Objective

Assessing the advantage of x-ray dark-field contrast over x-ray transmission contrast in radiography for the detection of developing radiation-induced lung damage in mice.

Methods

Two groups of female C57BL/6 mice (irradiated and control) were imaged obtaining both contrasts monthly for 28 weeks post irradiation. Six mice received 20 Gy of irradiation to the entire right lung sparing the left lung. The control group of six mice was not irradiated. A total of 88 radiographs of both contrasts were evaluated for both groups based on average values for two regions of interest, covering (irradiated) right lung and healthy left lung. The ratio of these average values, R, was distinguished between healthy and damaged lungs for both contrasts. The time-point when deviation

SUBMITTER: Burkhardt R 

PROVIDER: S-EPMC8128748 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature