Time Course of Hemostatic Disruptions After Traumatic Brain Injury: A Systematic Review of the Literature.

ABSTRACT: Almost two-thirds of patients with severe traumatic brain injury (TBI) develop some form of hemostatic disturbance, which contributes to poor outcome. While the initial head injury often leads to impaired clot formation, TBI is also associated with an increased risk of thrombosis. Most likely there is a progression from early bleeding to a later prothrombotic state. In this paper, we systematically review the literature on the time course of hemostatic disruptions following TBI. A MEDLINE search was performed for TBI studies reporting the trajectory of hemostatic assays over time. The search yielded 5,049 articles, of which 4,910 were excluded following duplicate removal as well as title and abstract review. Full-text assessment of the remaining articles yielded 33 studies that were includ

SUBMITTER: Fletcher-Sandersjoo A 

PROVIDER: S-EPMC8128788 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature