Feasibility and diagnostic accuracy of using brain attenuation changes on CT to estimate time of ischemic stroke onset.

ABSTRACT:

Purpose

CT attenuation of ischemic brain reduces with time after stroke onset. We aimed to quantify this relationship and test the feasibility and accuracy of estimating stroke onset time using only CT attenuation of visible ischemic lesions, the CT-Clock Tool.

Methods

We selected CT scans with ischemic lesions representing a range of stroke-onset-to-scan times (elapsed time) from a well-defined stroke trial. We measured the attenuation of ischemic lesions and contralateral normal brain to derive attenuation ratio. We assigned scans to development (75%) or test (25%) datasets. We plotted the relationship between attenuation ratio and elapsed time in the development dataset and derived a best-fit curve. We calculated estimated time in the test dataset using only the attenuati

SUBMITTER: Mair G 

PROVIDER: S-EPMC8128810 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature