Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential.

ABSTRACT: Human pluripotent stem cells (hPSCs) can generate specialized cell lineages that have great potential for regenerative therapies and disease modeling. However, the developmental stage of the lineages generated from conventional hPSC cultures in vitro are embryonic in phenotype, and may not possess the cellular maturity necessary for corrective regenerative function in vivo in adult recipients. Here, we present the scientific evidence for how adult human tissues could generate human-animal interspecific chimeras to solve this problem. First, we review the phenotypes of the embryonic lineages differentiated from conventional hPSC in vitro and through organoid technologies and compare their functional relevance to the tissues generated during normal human in utero fetal and adult development.

SUBMITTER: Thomas J 

PROVIDER: S-EPMC8128894 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature