Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe^-/- mice.

ABSTRACT: The calcium sensing receptor (CaSR) is a G-protein coupled receptor that especially plays an important role in the sensing of extracellular calcium to maintain its homeostasis. Several in-vitro studies demonstrated that CaSR plays a role in adipose tissue metabolism and inflammation, resulting in systemic inflammation and contributing to atherosclerosis development. The aim of this study was to investigate whether adipocyte CaSR plays a role in adipose tissue inflammation in-vivo and atherosclerosis development. By using a newly established conditional mature adipocyte specific CaSR deficient mouse on a hyperlipidemic and atherosclerosis prone Apoe^-/- background it could be shown that CaSR deficiency in adipocytes does neither contribute to initiation nor to progression of ather

SUBMITTER: Sundararaman SS 

PROVIDER: S-EPMC8128899 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature