Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice.

ABSTRACT: The complement system plays a role in the formation of sub-retinal pigment epithelial (RPE) deposits in early stages of age-related macular degeneration (AMD). But the specific mechanisms that connect complement activation and deposit formation in AMD patients are unknown, which limits the development of efficient therapies to reduce or stop disease progression. We have previously demonstrated that C3 blockage prevents the formation of sub-RPE deposits in a mouse model of EFEMP1-associated macular degeneration. In this study, we have used double mutant Efemp1^R345W/R345W:C5^-/- mice to investigate the role of C5 in the formation of sub-RPE deposits in vivo and in vitro. The data revealed that the genetic ablation of C5 does not eliminate the formation of sub-RPE deposit

SUBMITTER: Garland DL 

PROVIDER: S-EPMC8128922 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature