Net decrease in spine-surface GluA1-containing AMPA receptors after post-learning sleep in the adult mouse cortex.

ABSTRACT: The mechanisms by which sleep benefits learning and memory remain unclear. Sleep may further strengthen the synapses potentiated by learning or promote broad synaptic weakening while protecting the newly potentiated synapses. We tested these ideas by combining a motor task whose consolidation is sleep-dependent, a marker of synaptic AMPA receptor plasticity, and repeated two-photon imaging to track hundreds of spines in vivo with single spine resolution. In mouse motor cortex, sleep leads to an overall net decrease in spine-surface GluA1-containing AMPA receptors, both before and after learning. Molecular changes in single spines during post-learning sleep are correlated with changes in performance after sleep. The spines in which learning leads to the largest increase in GluA1 expression

SUBMITTER: Miyamoto D 

PROVIDER: S-EPMC8129120 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature