Calibration of a Heterogeneous Brain Model Using a Subject-Specific Inverse Finite Element Approach.

ABSTRACT: Central to the investigation of the biomechanics of traumatic brain injury (TBI) and the assessment of injury risk from head impact are finite element (FE) models of the human brain. However, many existing FE human brain models have been developed with simplified representations of the parenchyma, which may limit their applicability as an injury prediction tool. Recent advances in neuroimaging techniques and brain biomechanics provide new and necessary experimental data that can improve the biofidelity of FE brain models. In this study, the CAB-20MSym template model was developed, calibrated, and extensively verified. To implement material heterogeneity, a magnetic resonance elastography (MRE) template image was leveraged to define the relative stiffness gradient of the brain model. A mult

SUBMITTER: Giudice JS 

PROVIDER: S-EPMC8129184 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature