Identification of key gene modules and pathways of human platelet transcriptome in acute myocardial infarction patients through co-expression network.

ABSTRACT: Acute myocardial infarction (AMI) seriously threatens human life. In this study we aimed to systemically analyze the function of key gene modules in human platelets in AMI. We used weighted gene co-expression network analysis (WGCNA) to construct a co-expression module, and analyzed the relationship between potential modules and clinical characteristics based on platelet RNA-seq RPKM count reads of 16 ST-segment elevation myocardial infarction (STEMI) patients and 16 non-STEMI (NSTEMI) patients provided by the GEO database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed with the DAVID tool. Hub genes were calculated by the Cytohubba package. A total of 3653 genes was selected to construct the co-expression modules. A significant correlation be

SUBMITTER: Zhang B 

PROVIDER: S-EPMC8129354 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature