Characterisation of progestins used in hormonal contraception and progesterone via the progesterone receptor.

ABSTRACT: Different progestogens are widely used in hormonal therapy and mediate their therapeutic actions via the progesterone receptor (PR). Little published data exist on their relative efficacies and potencies via the PR, while those available may be confounded by off-target receptors, different methodologies and model systems. We performed dose-response analysis to investigate the efficacies and potencies for transcription of progesterone and several progestins widely used in contraception via the B isoform of human PR (PR-B). We compared responses using three different cell lines and two different transient transfection conditions. Results show that in vitro biological responses via PR-B for the select progestogens can vary significantly in biocharacter, rank order and absolute values for effi

SUBMITTER: Enfield K 

PROVIDER: S-EPMC8129485 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature