Ontology highlight
ABSTRACT:
SUBMITTER: Uryash A
PROVIDER: S-EPMC8129504 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Uryash Arkady A Mijares Alfredo A Esteve Eric E Adams Jose A JA Lopez Jose R JR
Frontiers in physiology 20210504
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting and the development of a dilated cardiomyopathy (DCM), which is the leading cause of death in DMD patients. Despite knowing the cause of DMD, there are currently no therapies which can prevent or reverse its inevitable progression. We have used whole body periodic acceleration (WBPA) as a novel tool to enhance intracellular constitutive nitric oxide (NO) production. WBPA adds small pulses to the circulation to incre ...[more]