The use of expanded carrier screening of gamete donors.

ABSTRACT:

Study question

What are the sperm and egg donor rejection rates after expanded carrier screening (ECS)?

Summary answer

Using an ECS panel looking at 46/47 genes, 17.6% of donors were rejected.

What is known already

The use of ECS is becoming commonplace in assisted reproductive technology, including testing of egg and sperm donors. Most national guidelines recommend rejection of donors if they are carriers of a genetic disease. If the use of ECS increases, there will be a decline in the number of donors available.

Study design, size, duration

A review of the current preconception ECS panels available to donors was carried out through an online search. The genetic testing results of donors from Cryos International were analysed to determine how many were rejecte

SUBMITTER: Payne MR 

PROVIDER: S-EPMC8129592 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature