Algebraic expressions for Carr-Purcell-Meiboom-Gill relaxation dispersion for N-site chemical exchange.

ABSTRACT: The Carr-Purcell-Meiboom-Gill (CPMG) NMR relaxation dispersion experiment measures the effective relaxation rate constant during a train of spin-echo pulse sequence elements as a function of the echo time. The CPMG experiment is a powerful method for characterizing chemical and conformational dynamic processes, termed chemical and conformational exchange, on μs-ms time scales, comparable to the experimentally accessible echo times. Approximate theoretical expressions for the effective relaxation rate constant for N-site chemical exchange have been reported (H. Koss, M. Rance, and A. G. Palmer, Biochemistry 57, 4753-4763 (2018)). Expressions for the effective relaxation rate constant have been improved by using the Cayley-Hamilton theorem to obtain simple and accurate approximations of the

SUBMITTER: Koss H 

PROVIDER: S-EPMC8129722 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature