Association of Increased Prostate-Specific Antigen Levels After Treatment and Mortality in Men With Locally Advanced vs Localized Prostate Cancer: A Secondary Analysis of 2 Randomized Clinical Trials.

ABSTRACT:

Importance

Increased prostate-specific antigen (PSA) levels after treatment (PSA failure) may have different associations with outcomes for men with locally advanced vs localized prostate cancer.

Objective

To evaluate whether the association between PSA failure and death may be different in locally advanced vs localized prostate cancer.

Design, setting, and participants

This multicenter cohort study included patients from 2 randomized clinical trials. The Dana-Farber Cancer Institute (DFCI) 95-096 trial randomized 206 men with localized prostate cancer from December 1, 1995, to April 15, 2001, whereas the European Organisation for Research and Treatment of Cancer (EORTC) 22961 trial randomized 970 men with locally advanced prostate cancer from October 30, 1997, to May

SUBMITTER: King MT 

PROVIDER: S-EPMC8129819 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature