Dataset Information

US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention.

ABSTRACT:

Importance

Asthma is the leading chronic illness in US children, but most descriptive epidemiological data are focused on prevalence.

Objective

To evaluate childhood asthma incidence rates across the nation by core demographic strata and parental history of asthma.

Design, setting, and participants

For this cohort study, a distributed meta-analysis was conducted within the Environmental Influences on Child Health Outcomes (ECHO) consortium for data collected from May 1, 1980, through March 31, 2018. Birth cohort data of children from 34 gestational weeks of age or older to 18 years of age from 31 cohorts in the ECHO consortium were included. Data were analyzed from June 14, 2018, to February 18, 2020.

Exposures

Caregiver report of physician-diagnosed asthma with age of diagnosis.

Main outcome and measures

Asthma incidence survival tables generated by each cohort were combined for each year of age using the Kaplan-Meier method. Age-specific incidence rates for each stratum and asthma incidence rate ratios by parental family history (FH), sex, and race/ethnicity were calculated.

Results

Of the 11 404 children (mean [SD] age, 10.0 [0.7] years; 5836 boys [51%]; 5909 White children [53%]) included in the primary analysis, 7326 children (64%) had no FH of asthma, 4078 (36%) had an FH of asthma, and 2494 (23%) were non-Hispanic Black children. Children with an FH had a nearly 2-fold higher incidence rate through the fourth year of life (incidence rate ratio [IRR], 1.94; 95% CI, 1.76-2.16) after which the rates converged with the non-FH group. Regardless of FH, asthma incidence rates among non-Hispanic Black children were markedly higher than those of non-Hispanic White children during the preschool years (IRR, 1.58; 95% CI, 1.31-1.86) with no FH at age 4 years and became lower than that of White children after age 9 to 10 years (IRR, 0.67; 95% CI, 0.50-0.89) with no FH. The rates for boys declined with age, whereas rates among girls were relatively steady across all ages, particularly among those without an FH of asthma.

Conclusions and relevance

Analysis of these diverse birth cohorts suggests that asthma FH, as well as race/ethnicity and sex, were all associated with childhood asthma incidence rates. Black children had much higher incidences rates but only during the preschool years, irrespective of FH. To prevent asthma among children with an FH of asthma or among Black infants, results suggest that interventions should be developed to target early life.

SUBMITTER: Johnson CC

PROVIDER: S-EPMC8129904 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention.

Johnson Christine Cole CC Chandran Aruna A Havstad Suzanne S Li Xiuhong X McEvoy Cynthia T CT Ownby Dennis R DR Litonjua Augusto A AA Karagas Margaret R MR Camargo Carlos A CA Gern James E JE Gilliland Frank F Togias Alkis A

JAMA pediatrics 20210901 9

<h4>Importance</h4>Asthma is the leading chronic illness in US children, but most descriptive epidemiological data are focused on prevalence.<h4>Objective</h4>To evaluate childhood asthma incidence rates across the nation by core demographic strata and parental history of asthma.<h4>Design, setting, and participants</h4>For this cohort study, a distributed meta-analysis was conducted within the Environmental Influences on Child Health Outcomes (ECHO) consortium for data collected from May 1, 198 ...[more]

PMID: 33999100

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Dataset Information

US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention.

Importance

Objective

Design, setting, and participants

Exposures

Main outcome and measures

Results

Conclusions and relevance

Publications

US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention.

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