Ontology highlight
ABSTRACT:
SUBMITTER: Reizel Y
PROVIDER: S-EPMC8129911 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Reizel Yitzhak Y Morgan Ashleigh A Gao Long L Schug Jonathan J Mukherjee Sarmistha S García Meilín Fernández MF Donahue Greg G Baur Joseph A JA Zaret Kenneth S KS Kaestner Klaus H KH
Developmental cell 20210225 5
Tissue-specific DNA methylation patterns are created by transcription factors that recruit methylation and demethylation enzymes to cis-regulatory elements. To date, it is not known whether transcription factors are needed to continuously maintain methylation profiles in development and mature tissues or whether they only establish these marks during organ development. We queried the role of the pioneer factor FoxA in generating hypomethylated DNA at liver enhancers. We discovered a set of FoxA- ...[more]