Bifunctional Nitrone-Conjugated Secondary Metabolite Targeting the Ribosome.

ABSTRACT: Many microorganisms possess the capacity for producing multiple antibiotic secondary metabolites. In a few notable cases, combinations of secondary metabolites produced by the same organism are used in important combination therapies for treatment of drug-resistant bacterial infections. However, examples of conjoined roles of bioactive metabolites produced by the same organism remain uncommon. During our genetic functional analysis of oxidase-encoding genes in the everninomicin producer Micromonospora carbonacea var. aurantiaca, we discovered previously uncharacterized antibiotics everninomicin N and O, comprised of an everninomicin fragment conjugated to the macrolide rosamicin via a rare nitrone moiety. These metabolites were determined to be hydrolysis products of evernino

SUBMITTER: Limbrick EM 

PROVIDER: S-EPMC8129991 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature