Adolescent residential mobility, genetic liability and risk of schizophrenia, bipolar disorder and major depression.

ABSTRACT:

Background

Residential mobility during upbringing, and especially adolescence, is associated with multiple negative mental health outcomes. However, whether associations are confounded by unmeasured familial factors, including genetic liability, is unclear.

Aims

We used a population-based case-cohort study to assess whether polygenic risk scores (PRSs) for schizophrenia, bipolar disorder and major depression were associated with mobility from ages 10-14 years, and whether PRS and parental history of mental disorder together explained associations between mobility and each disorder.

Method

Information on cases (n = 4207 schizophrenia, n = 1402 bipolar disorder, n = 18 215 major depression) and a random population sample (n = 17 582), born 1981-1997, was linked between

SUBMITTER: Paksarian D 

PROVIDER: S-EPMC8130005 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature