Metabolites Associated With Malnutrition in the Intensive Care Unit Are Also Associated With 28-Day Mortality.

ABSTRACT:

Background

We hypothesized that metabolic profiles would differ in critically ill patients with malnutrition relative to those without.

Materials and methods

We performed a prospective cohort study on 85 adult patients with systemic inflammatory response syndrome or sepsis admitted to a 20-bed medical intensive care unit (ICU) in Boston. We generated metabolomic profiles using gas and liquid chromatography and mass spectroscopy. We followed this by logistic regression and partial least squares discriminant analysis to identify individual metabolites that were significant. We then interrogated the entire metabolomics profile using metabolite set enrichment analysis and network model construction of chemical-protein target interactions to identify groups of metabolites and pat

SUBMITTER: Mogensen KM 

PROVIDER: S-EPMC8130016 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature