SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition.
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ABSTRACT:
SUBMITTER: Altmann DM
PROVIDER: S-EPMC8130189 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition.
Altmann Daniel M DM Reynolds Catherine J CJ Boyton Rosemary J RJ
Cell reports. Medicine 20210501 5
COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type. ...[more]
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