SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition.

ABSTRACT: COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.

SUBMITTER: Altmann DM 

PROVIDER: S-EPMC8130189 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature