Multifunctional nanoplatforms as cascade-responsive drug-delivery carriers for effective synergistic chemo-photodynamic cancer treatment.

ABSTRACT: Synergistic chemo-photodynamic therapy has garnered attention in the field of cancer treatment. Here, a pH cascade-responsive micellar nanoplatform with nucleus-targeted ability, for effective synergistic chemo-photodynamic cancer treatment, was fabricated. In this micellar nanoplatform, 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin (Por), a photodynamic therapy (PDT) agent was utilized for carrying the novel anticancer drug GNA002 to construct a hydrophobic core, and cyclic RGD peptide (cRGD)-modified polyethylene glycol (PEG) (cRGD-PEG) connected the cell-penetrating peptide hexaarginine (R₆) through a pH-responsive hydrazone bond (cRGD-PEG-N = CH-R₆) to serve as a hydrophilic shell for increasing blood circulation time. After passively accumulating in tumor sites

SUBMITTER: Li F 

PROVIDER: S-EPMC8130269 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature