Dataset Information
Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia.
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ABSTRACT: Background
Coxsackievirus A21 (CVA21), a member of Enterovirus C from the Picornaviridae family, has been associated with respiratory illnesses in humans.Methods
A molecular epidemiological investigation of CVA21 was conducted among patients presenting with acute upper respiratory illnesses in the ambulatory settings between 2012 and 2014 in Kuala Lumpur, Malaysia.Results
Epidemiological surveillance of acute respiratory infections (n = 3935) showed low-level detection of CVA21 (0.08%, 1.4 cases/year) in Kuala Lumpur, with no clear seasonal distribution. Phylogenetic analysis of the new complete genomes showed close relationship with CVA21 strains from China and the United States. Spatio-temporal mapping of the VP1 gene determined 2 major clusters circulating worldwide, with inter-country lineage migration and strain replacement occurring over time.Conclusions
The study highlights the emerging role of CVA21 in causing sporadic acute respiratory outbreaks.
SUBMITTER: Supian NI
PROVIDER: S-EPMC8130276 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia.
BMC infectious diseases 20210517 1
<h4>Background</h4>Coxsackievirus A21 (CVA21), a member of Enterovirus C from the Picornaviridae family, has been associated with respiratory illnesses in humans.<h4>Methods</h4>A molecular epidemiological investigation of CVA21 was conducted among patients presenting with acute upper respiratory illnesses in the ambulatory settings between 2012 and 2014 in Kuala Lumpur, Malaysia.<h4>Results</h4>Epidemiological surveillance of acute respiratory infections (n = 3935) showed low-level detection of ...[more]