Causal relationship of CA3 back-projection to the dentate gyrus and its role in CA1 fast ripple generation.

ABSTRACT:

Background

Pathophysiological evidence from temporal lobe epilepsy models highlights the hippocampus as the most affected structure due to its high degree of neuroplasticity and control of the dynamics of limbic structures, which are necessary to encode information, conferring to it an intrinsic epileptogenicity. A loss in this control results in observable oscillatory perturbations called fast ripples, in epileptic rats those events are found in CA1, CA3, and the dentate gyrus (DG), which are the principal regions of the trisynaptic circuit of the hippocampus. The present work used Granger causality to address which relationships among these three regions of the trisynaptic circuit are needed to cause fast ripples in CA1 in an in vivo model. For these purposes, male Wistar rats (2

SUBMITTER: Nunez-Ochoa MA 

PROVIDER: S-EPMC8130286 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature