Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis.

ABSTRACT:

Background

Environmental stimuli experienced by the parental generation influence the phenotype of subsequent generations (Demoinet et al., Proc Natl Acad Sci U S A 114:E2689-E2698, 2017; Burton et al., Nat Cell Biol 19:252-257, 2017; Agrawal et al., Nature 401:60-63, 1999). The effects of these stimuli on the parental generation may be passed through the germline, but the mechanisms at the basis of this non-Mendelian type of inheritance, their level of conservation, how they lead to adaptive vs non-adaptive, and intergenerational vs transgenerational inheritance are poorly understood. Here we show that modulation of nutrient-sensing pathways in the parental generation of the nematode Auanema freiburgensis regulates phenotypic plasticity of its offspring.

Results

In response

SUBMITTER: Robles P 

PROVIDER: S-EPMC8130380 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature