Measuring and modeling energy and power consumption in living microbial cells with a synthetic ATP reporter.

ABSTRACT:

Background

Adenosine triphosphate (ATP) is the main energy carrier in living organisms, critical for metabolism and essential physiological processes. In humans, abnormal regulation of energy levels (ATP concentration) and power consumption (ATP consumption flux) in cells is associated with numerous diseases from cancer, to viral infection and immune dysfunction, while in microbes it influences their responses to drugs and other stresses. The measurement and modeling of ATP dynamics in cells is therefore a critical component in understanding fundamental physiology and its role in pathology. Despite the importance of ATP, our current understanding of energy dynamics and homeostasis in living cells has been limited by the lack of easy-to-use ATP sensors and the lack of models that en

SUBMITTER: Deng Y 

PROVIDER: S-EPMC8130387 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature