Treatment patterns and outcomes of older patients with mantle cell lymphoma in an Asian population.

ABSTRACT:

Background

Significant progress has been made in the treatment outcomes of mantle cell lymphoma (MCL) since the introduction of cytarabine and rituximab in modern regimens. However, older patients may not readily tolerate these agents nor derive benefit. We investigated the impact of age on treatment patterns and clinical outcomes of MCL patients in an Asian population.

Methods

A retrospective study was conducted on patients (n = 66) diagnosed with MCL at the National Cancer Centre Singapore between 1998 and 2018. The median follow-up duration was 40 months. Survival analyses were performed using the Kaplan-Meier method and multivariate Cox proportional models.

Results

The median age of the cohort was 59 years (range, 26-84), with a male predominance (73%). The majori

SUBMITTER: Yang X 

PROVIDER: S-EPMC8130422 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature