Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration.

ABSTRACT: Tauopathies are a group of neurodegenerative diseases characterized by the alteration/aggregation of TAU protein, for which there is still no effective treatment. Therefore, new pharmacological targets are being sought, such as elements of the endocannabinoid system (ECS). We analysed the occurrence of changes in the ECS in tauopathies and their implication in the pathogenesis. By integrating gene expression analysis, immunofluorescence, genetic and adeno-associated virus expressing TAU mouse models, we found a TAU-dependent increase in CB₂ receptor expression in hippocampal neurons, that occurs as an early event in the pathology and was maintained until late stages. These changes were accompanied by alterations in the endocannabinoid metabolism. Remarkably, CB₂ ablat

SUBMITTER: Galan-Ganga M 

PROVIDER: S-EPMC8130522 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature