Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium-dependent, non-D₂ receptor-dependent, manner.

ABSTRACT: Dopamine D₂ -like receptor antagonists have been suggested as being potential anticancer therapeutics with specific utility for central nervous system cancers due to their ability to cross the blood-brain barrier. Despite a plethora of data reporting anticancer effects for D₂ R antagonists in cell or animal studies, the ligand concentrations or doses required to achieve such effects greatly exceed the levels known to cause high degrees of occupancy of the D₂ receptor. To resolve this conundrum, we interrogated a panel of glioblastoma multiforme (GBM) cell lines using D₂ antagonists of varying chemotype. We studied the cytotoxic effects of these compounds, and also ascertained the expression of D₂ receptors (D₂ R) on these ce

SUBMITTER: Weissenrieder JS 

PROVIDER: S-EPMC8130568 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature