Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase.

ABSTRACT: Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of Mycobacterium tuberculosis. Herein, we report that ICLs form a covalent adduct with itaconate through their catalytic cysteine residue. These results reveal atomic details of itaconate inhibition and provide insights into the catalytic mechanism of ICLs.

SUBMITTER: Kwai BXC 

PROVIDER: S-EPMC8130629 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature