Triggers, Timescales, and Treatments for Cytokine-Mediated Tissue Damage.

ABSTRACT: Inflammation is an essential cytokine-mediated process for generating a neutralizing immune response against pathogens and is generally protective. However, aberrant or excessive production of pro-inflammatory cytokines is associated with uncontrolled local and systemic inflammation, resulting in cell death and often irreversible tissue damage. Uncontrolled inflammation can manifest over timescales spanning hours to years and is primarily dependent on the triggering event. Rapid and potentially lethal increase in cytokine production, or a 'cytokine storm,' develops in hours to days and is associated with cancer cell-based immunotherapies, such as CAR-T cell therapy. On the other hand, some bacterial and viral infections with high microbial replication or highly potent antigens elicit immun

SUBMITTER: McBride DA 

PROVIDER: S-EPMC8130813 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature