Transgenerational disease specific epigenetic sperm biomarkers after ancestral exposure to dioxin.

ABSTRACT: Dioxin was historically one of the most common industrial contaminants with several major industry accidents, as well as governmental actions involving military service, having exposed large numbers of the worldwide population over the past century. Previous rat studies have demonstrated the ability of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)) exposure to promote the epigenetic transgenerational inheritance of disease susceptibility in subsequent generations. The types of disease previously observed include puberty abnormalities, testis, ovary, kidney, prostate and obesity pathologies. The current study was designed to use an epigenome-wide association study (EWAS) to identify potential sperm DNA methylation biomarkers for specific transgenerational diseases. Therefore, the trans

SUBMITTER: Ben Maamar M 

PROVIDER: S-EPMC8130889 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature