An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.

ABSTRACT: Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal-hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) and complemented the dataset with our own new data. By confronting the effect of brain state and recor

SUBMITTER: Sanchez-Aguilera A 

PROVIDER: S-EPMC8130934 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature