Therapy for Alzheimer's disease: Missing targets and functional markers?

ABSTRACT: The development of the next generation therapy for Alzheimer's disease (AD) presents a huge challenge given the number of promising treatment candidates that failed in trials, despite recent advancements in understanding of genetic, pathophysiologic and clinical characteristics of the disease. This review reflects some of the most current concepts and controversies in developing disease-modifying and new symptomatic treatments. It elaborates on recent changes in the AD research strategy for broadening drug targets, and potentials of emerging non-pharmacological treatment interventions. Established and novel biomarkers are discussed, including emerging cerebrospinal fluid and plasma biomarkers reflecting tau pathology, neuroinflammation and neurodegeneration. These fluid biomarkers together

SUBMITTER: Stoiljkovic M 

PROVIDER: S-EPMC8131215 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature