Second surgery for progressive glioblastoma: a multi-centre questionnaire and cohort-based review of clinical decision-making and patient outcomes in current practice.

ABSTRACT:

Purpose

Glioblastoma prognosis is poor. Treatment options are limited at progression. Surgery may benefit, but no quality guidelines exist to inform patient selection. We sought to describe variations in surgical management at progression, highlight where further evidence is needed, and build towards a consensus strategy.

Methods

Current practice in selection of patients with progressive GBM for second surgery was surveyed online amongst specialists in the UK and Europe. We complemented this with an assessment of practice in a retrospective cohort study from six United Kingdom neurosurgical units. We used descriptive statistics to analyse the data.

Results

234 questionnaire responses were received. Maintaining or improving patient quality of life was key to decision m

SUBMITTER: Brennan PM 

PROVIDER: S-EPMC8131335 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature