Population-based body-brain mapping links brain morphology with anthropometrics and body composition.

ABSTRACT: Understanding complex body-brain processes and the interplay between adipose tissue and brain health is important for understanding comorbidity between psychiatric and cardiometabolic disorders. We investigated associations between brain structure and anthropometric and body composition measures using brain magnetic resonance imaging (MRI; n = 24,728) and body MRI (n = 4973) of generally healthy participants in the UK Biobank. We derived regional and global measures of brain morphometry using FreeSurfer and tested their association with (i) anthropometric measures, and (ii) adipose and muscle tissue measured from body MRI. We identified several significant associations with small effect sizes. Anthropometric measures showed negative, nonlinear, associations with cerebellar/cortical gray ma

SUBMITTER: Gurholt TP 

PROVIDER: S-EPMC8131380 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature