Adiponectin Mediates the Protection of H₂S Against Chronic Restraint Stress-Induced Cognitive Impairment via Attenuating Hippocampal Damage.

ABSTRACT: Emerging evidence shows that chronic restraint stress (CRS) can induce cognitive dysfunction, which involves in hippocampal damage. Our recent research reveals that hydrogen sulfide (H₂S), a novel gasotransmitter, protects against CRS-induced cognitive impairment, but the underlying mechanism remains unclear. Adiponectin, the most abundant plasma adipokine, has been shown to elicit neuroprotective property and attenuate cognitive impairment. Hence, the present work was aimed to explore whether adiponectin mediates the protective effect of H₂S on CRS-induced cognitive impairment by inhibiting hippocampal damage. Results found that administration of Anti-Acrp30, a neutralizing antibody of adiponectin, obviously reverses sodium hydrosulfide (NaHS, an exogenous H₂

SUBMITTER: Tang QY 

PROVIDER: S-EPMC8131522 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature