Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories.

ABSTRACT: The development and function of the central nervous system rely on the microtubule (MT) and actin cytoskeletons and their respective effectors. Although the structural role of the cytoskeleton has long been acknowledged in neuronal morphology and activity, it was recently recognized to play the role of a signaling platform. Following this recognition, research into Microtubule Associated Proteins (MAPs) diversified. Indeed, historically, structural MAPs-including MAP1B, MAP2, Tau, and MAP6 (also known as STOP);-were identified and described as MT-binding and -stabilizing proteins. Extensive data obtained over the last 20 years indicated that these structural MAPs could also contribute to a variety of other molecular roles. Among multi-role MAPs, MAP6 provides a striking example illustratin

SUBMITTER: Cuveillier C 

PROVIDER: S-EPMC8131560 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature