Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities.

ABSTRACT: Antimicrobial resistance seriously threatened human health, and new antimicrobial agents are desperately needed. As one of the largest classes of plant secondary metabolite, flavonoids can be widely found in various parts of the plant, and their antibacterial activities have been increasingly paid attention to. Based on the physicochemical parameters and antibacterial activities of sixty-six flavonoids reported, two regression equations between their ACD/LogP or LogD_7.40 and their minimum inhibitory concentrations (MICs) to gram-positive bacteria were established with the correlation coefficients above 0.93, and then were verified by another sixty-eight flavonoids reported. From these two equations, the MICs of most flavonoids against gram-positive bacteria could be roughly calc

SUBMITTER: Yuan G 

PROVIDER: S-EPMC8131645 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature