Latent CMV Infection Is Associated With Lower Influenza Virus-Specific Memory T-Cell Frequencies, but Not With an Impaired T-Cell Response to Acute Influenza Virus Infection.

ABSTRACT: Latent infection with cytomegalovirus (CMV) is assumed to contribute to the age-associated decline of the immune system. CMV induces large changes in the T-cell pool and may thereby affect other immune responses. CMV is expected to impact especially older adults, who are already at higher risk of severe disease and hospitalization upon infections such as influenza virus (IAV) infection. Here, we investigated the impact of CMV infection on IAV-specific CD8⁺ T-cell frequencies in healthy individuals (n=96) and the response to IAV infection in older adults (n=72). IAV-specific memory T-cell frequencies were lower in healthy CMV⁺ older individuals compared to healthy CMV^- older individuals. Upon acute IAV infection, CMV serostatus or CMV-specific antibody level

SUBMITTER: van den Berg SPH 

PROVIDER: S-EPMC8131658 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature