Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload.

ABSTRACT:

Objective

The molecular pathogenesis of late complications associated with type 2 diabetes mellitus (T2DM) is not yet fully understood. While high glucose levels indicated by increased HbA1c only poorly explain disease progression and late complications, a pro-inflammatory status, oxidative stress, and reactive metabolites generated by metabolic processes were postulated to be involved. Individuals with metabolic syndrome (MetS) frequently progress to T2DM, whereby 70% of patients with T2DM show non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of MetS, and insulin resistance (IR). Epidemiological studies have shown that T2DM and steatosis are associated with alterations in iron metabolism and hepatic iron accumulation. Excess free iron triggers oxidative stress

SUBMITTER: Altamura S 

PROVIDER: S-EPMC8131719 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature