MiRNA-Based Therapeutics in Breast Cancer: A Systematic Review.

ABSTRACT:

Background

Breast cancer (BC) is the most common cancer in females and despite advances in treatment, it represents the leading cause of cancer mortality in women worldwide. Conventional therapeutic modalities have significantly improved the management of BC patients, but subtype heterogeneity, drug resistance, and tumor relapse remain the major factors to hamper the effectiveness of therapy for BC. In this scenario, miRNA(miR)-based therapeutics offer a very attractive area of study. However, the use of miR-based therapeutics for BC treatment still represents an underdeveloped topic. Therefore, this systematic review aims at summarizing current knowledge on promising miR-based therapeutics for BC exploring original articles focusing on in vivo experiments.

Methods

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SUBMITTER: Grimaldi AM 

PROVIDER: S-EPMC8131824 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature