Association vs. Prediction: The Impact of Cortical Surface Smoothing and Parcellation on Brain Age.

ABSTRACT: Association and prediction studies of the brain target the biological consequences of aging and their impact on brain function. Such studies are conducted using different smoothing levels and parcellations at the preprocessing stage, on which their results are dependent. However, the impact of these parameters on the relationship between association values and prediction accuracy is not established. In this study, we used cortical thickness and its relationship with age to investigate how different smoothing and parcellation levels affect the detection of age-related brain correlates as well as brain age prediction accuracy. Our main measures were resel numbers-resolution elements-and age-related variance explained. Using these common measures enabled us to directly compare parcellation an

SUBMITTER: Zeighami Y 

PROVIDER: S-EPMC8131952 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature