Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways.

ABSTRACT: Toxicogenomics opens novel opportunities for hazard assessment by utilizing computational methods to map molecular events and biological processes. In this study, the transcriptomic and immunopathological changes associated with airway exposure to a total of 28 engineered nanomaterials (ENM) are investigated. The ENM are selected to have different core (Ag, Au, TiO₂, CuO, nanodiamond, and multiwalled carbon nanotubes) and surface chemistries (COOH, NH₂, or polyethylene glycosylation (PEG)). Additionally, ENM with variations in either size (Au) or shape (TiO₂) are included. Mice are exposed to 10 µg of ENM by oropharyngeal aspiration for 4 consecutive days, followed by extensive histological/cytological analyses and transcriptomic characterization of lung ti

SUBMITTER: Kinaret PAS 

PROVIDER: S-EPMC8132046 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature