An Insulin-Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes.

ABSTRACT: Supramolecular peptide hydrogel has shown promising potential in vaccine development largely because of its ability to function both as antigen depot and immune adjuvant. Nap-G^dF^dF^dY, a tetrapeptide hydrogel that has been previously reported to exhibit adjuvant effect, is inadvertently found to contain conserved peptide sequence for insulin, proinsulin, and glutamic acid decarboxylase, 3 major autoantigens for the autoimmune type 1 diabetes (T1D). At present, despite being managed clinically with insulin replacement therapy, T1D remains a major health threat with rapidly increasing incidences, especially in children and young adults, and antigen-specific immune tolerance induction has been proposed as a feasible approach to prevent or delay T1D progression

SUBMITTER: Liu M 

PROVIDER: S-EPMC8132061 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature