Regulation of microRNA-221, -222, -21 and -27 in articular cartilage subjected to abnormal compressive forces.

ABSTRACT:

Key points

microRNAs (miRs) are small non-coding molecules that regulate post-transcriptional target gene expression. miRs are involved in regulating cellular activities in response to mechanical loading in all physiological systems, although it is largely unknown whether this response differs with increasing magnitudes of load. miR-221, miR-222, miR-21-5p and miR-27a-5p were significantly increased in ex vivo cartilage explants subjected to increasing load magnitude and in in vivo joint cartilage exposed to abnormal loading. TIMP3 and CPEB3 are putative miR targets in chondrocytes Identification of mechanically regulated miRs that have potential to impact on tissue homeostasis provides a mechanism by which load-induced tissue behaviour is regulated, in both health and pathology, i

SUBMITTER: Stadnik PS 

PROVIDER: S-EPMC8132181 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature