Robotic in situ 3D bio-printing technology for repairing large segmental bone defects.

ABSTRACT:

Introduction

The traditional clinical treatment of long segmental bone defects usually requires multiple operations and depends on donor availability. The 3D bio-printing technology constitutes a great potential therapeutic tool for such an injury. However, in situ 3D bio-printing remains a major challenge.

Objectives

In this study, we report the repair of long segmental bone defects by in situ 3D bio-printing using a robotic manipulator 3D printer in a swine model.

Methods

We systematically optimized bio-ink gelation under physiological conditions to achieve desirable mechanical properties suitable for bone regeneration, and a D-H kinematic model was used to improve printing accuracy to 0.5 mm.

Results

These technical improvements allowed the rep

SUBMITTER: Li L 

PROVIDER: S-EPMC8132211 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature