Longitudinal immune profiling of a SARS-CoV-2 reinfection in a solid organ transplant recipient.

ABSTRACT: The underlying immunologic deficiencies enabling SARS-CoV-2 reinfections are currently unknown. Here we describe a renal-transplant recipient who developed recurrent, symptomatic SARS-CoV-2 infection 7 months after primary infection. To elucidate the immunological mechanisms responsible for reinfection, we performed longitudinal profiling of cellular and humoral responses during both primary and recurrent SARS-CoV-2 infection. We found that the patient responded to the primary infection with transient, poor-quality adaptive immune responses that was further compromised by intervening treatment for acute rejection of the renal allograft prior to reinfection. Importantly, we identified the development of neutralizing antibodies and humoral memory responses prior to SARS-CoV-2 reinfection. Ho

SUBMITTER: Klein J 

PROVIDER: S-EPMC8132249 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature