Gut Microbiome in Progressive Multiple Sclerosis.

ABSTRACT:

Objective

This study was undertaken to investigate the gut microbiome in progressive multiple sclerosis (MS) and how it relates to clinical disease.

Methods

We sequenced the microbiota from healthy controls and relapsing-remitting MS (RRMS) and progressive MS patients and correlated the levels of bacteria with clinical features of disease, including Expanded Disability Status Scale (EDSS), quality of life, and brain magnetic resonance imaging lesions/atrophy. We colonized mice with MS-derived Akkermansia and induced experimental autoimmune encephalomyelitis (EAE).

Results

Microbiota β-diversity differed between MS patients and controls but did not differ between RRMS and progressive MS or differ based on disease-modifying therapies. Disease status had the greatest eff

SUBMITTER: Cox LM 

PROVIDER: S-EPMC8132291 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature